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apo(a) transgenic rabbit

製作者

範　江林

導入遺伝子

apolipoprotein(a) (Human)

キーワード

Lp(a)，アポ蛋白，動脈硬化，心筋梗塞，動脈硬化病変の石灰化

特徴

製作者のページへリンク

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関連文献

• Kitajima, S., Jin, Y., Koike, T., Yu, Y., Liu, E., Morimoto, M., Shiomi, M., Marcovina, S., Watanabe, N. and Fan, J.: Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits. Atherosclerosis 193: 269-276, 2007.
• Watanabe, N., Nakagawa, H., Kitajima, S., Liu, E., Morimoto, M, Watanabe, T and Fan, J.: Establishment of a SPF colony of human apo(a) transgenic rabbits by frozen-thawed embryo transfer. Exp. Anim. 54(4): 353-357, 2005.
• Ichikawa T. Unoki H. Sun H. Shimoyamada H. Marcovina S. Shikama H. Watanabe T. Fan J.: Lipoprotein(a) promotes smooth muscle cell proliferation and dedifferentiation in atherosclerotic lesions of human apo(a) transgenic rabbits. American Journal of Pathology. 160(1):227-36, 2002.
• Sun H. Unoki H. Wang X. Liang J. Ichikawa T. Arai Y. Shiomi M. Marcovina SM. Watanabe T. Fan J.: Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a). Journal of Biological Chemistry. 277(49):47486-92, 2002.
• Fan J. Shimoyamada H. Sun H. Marcovina S. Honda K. Watanabe T.: Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet. Arteriosclerosis, Thrombosis & Vascular Biology. 21(1):88-94, 2001.
• Fan J. Sun H. Unoki H. Shiomi M. Watanabe T.: Enhanced atherosclerosis in Lp(a) WHHL transgenic rabbits. Annals of the New York Academy of Sciences. 947:362-5, 2001.
• Fan J. Watanabe T.: Transgenic rabbits expressing human apolipoprotein (a). Journal of Atherosclerosis & Thrombosis. 7(1):8-13, 2000.
• Fan J. Challah M. Shimoyamada H. Watanabe T.: Transgenic rabbits expressing human apolipoprotein(a) as a useful model for the study of lipoprotein(a). Annals of the New York Academy of Sciences. 902:347-51, 2000.
• Fan J. Araki M. Wu L. Challah M. Shimoyamada H. Lawn RM. Kakuta H. Shikama H. Watanabe T.: Assembly of lipoprotein (a) in transgenic rabbits expressing human apolipoprotein (a). Biochemical & Biophysical Research Communications. 255(3):639-44, 1999.

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