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C6-deficient rabbit

導入元

Johannes Gutenberg-University Mainz, Germany

キーワード

補体，compliment 6 (C6)，動脈硬化，感染症

特徴

補体成分のうち，第6成分(C6)を欠損しているため， 血中の補体活性（感作赤血球に対する溶血反応）を欠く。

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関連文献

• Reifenberg, K., Lehr, H-A., Fan,J., Koike, T., Wiese, R., Küpper, Sagban, TA., Schaefer, SC., Zähringer, U., Torzewski, M., Lackner, KJ, Bhakdi, S.: Endotoxin accelerates atherosclerosis independent of complement activation. Thromb Res, 123: 653-658, 2009.
• Liu, E., Kitajima, S., Wiese, E., Reifenberg, K., Morimoto, M., Watanabe, T. and Fan, J.: Re-establishment of Complement C6-deficeint Rabbit Colony by Cryopreserved Sperm Transported from Abroad. Exp. Anim. 55(2): 167-171, 2007.
• Schmiedt W, Kinscherf R, Deigner HP, Kamencic H, Nauen O, Kilo J, Oelert H, M etz J, Bhakdi S : Complement C6 deficiency protects against diet-induced atherosclerosis in rabbits. Arterioscle. Thromb Vasc Biol 18, 1790-1795, 1998.
• Rother K : Rabbits deficient in C6. Prog. Allergy 36, 192-201, 1986.

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