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Lipoprotein lipase (LPL) transgenic rabbit　（全身発現）

製作者

範　江林

導入遺伝子

Lipoprotein lipase (Human)

キーワード

リポ蛋白リパーゼ，高脂血症，動脈硬化，肥満

特徴

Chiken β-actin プロモーターにより、全身性にLPLの過剰発現が認められている
製作者のページへリンク

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関連文献

• Nishida, Y., Nishijima, K., Yamada, Y., Tanaka, H., Matsumoto, A., Fan, J., Uda, Y., Tomatsu, H., Yamamoto, H., Kami, K., Kitajima, S., and Tanaka, K.: Whole?body insulin resistance and energy expenditure indices, serum lipids, and skeletal muscle metabolome in a state of lipoprotein lipase overexpression. Metabolomics 17: 26, 2021.
• Koike T. Liang J. Wang X. Ichikawa T. Shiomi M. Sun H. Watanabe T. Liu G. Fan J.: Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase. Cardiovascular Research. 65(2):524-34, 2005.
• Liu E. Kitajima S. Higaki Y. Morimoto M. Sun H. Watanabe T. Yamada N. Fan J.: High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits. Metabolism: Clinical & Experimental. 54(1):132-8, 2005.
• Kitajima S. Morimoto M. Liu E. Koike T. Higaki Y. Taura Y. Mamba K. Itamoto K. Watanabe T. Tsutsumi K. Yamada N. Fan J.: Overexpression of lipoprotein lipase improves insulin resistance induced by a high-fat diet in transgenic rabbits. Diabetologia. 47(7):1202-9, 2004.
• Ichikawa T. Kitajima S. Liang J. Koike T. Wang X. Sun H. Okazaki M. Morimoto M. Shikama H. Watanabe T. Yamada N. Fan J.: Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Laboratory Investigation. 84(6):715-26, 2004.
• Koike T. Liang J. Wang X. Ichikawa T. Shiomi M. Liu G. Sun H. Kitajima S. Morimoto M. Watanabe T. Yamada N. Fan J.: Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity. Journal of Biological Chemistry. 279(9):7521-9, 2004.
• Koike T. Wang X. Unoki H. Liang J. Ichikawa T. Kitajima S. Watanabe T. Fan J.: Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles. Muscle & Nerve. 26(6):823-7, 2002.
• Fan J. Unoki H. Kojima N. Sun H. Shimoyamada H. Deng H. Okazaki M. Shikama H. Yamada N. Watanabe T.: Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis. Journal of Biological Chemistry. 276(43):40071-9, 2001.
• Araki, M., Fan, J., Challah, M., Bensadoun, A., Yamada, N., Honda, K. and Watanabe, T.: Transgenic rabbits expressing human lipoprotein lipase. Cytotechnology 33: 93-99, 2000.

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